Overdosing on Serotonin: What to Know About Serotonin Toxicity

Overdosing on Serotonin: What to Know About Serotonin Toxicity

Serotonin toxicity (ST) (aka serotonin syndrome) is a cluster of symptoms that develops with very high serotonin levels or serotonergic activity from direct agonists at certain serotonin receptors. It is most often seen with a combination of drugs, such as a monoamine oxidase inhibitor (MAOI) with a serotonin reuptake inhibitor (SRI), but it can also occur with a single drug, usually when a substantial overdose is used.

The effects of overly high serotonin exist on a spectrum. The mildest cases often won’t meet the diagnostic criteria for serotonin toxicity even though the observed symptoms are technically the result of high serotonin. This means a threshold of sorts must be crossed for serotonin toxicity to be diagnosed. Classically the condition has been defined as including symptoms from three categories: neuromuscular (arguably the most important), autonomic, and mental.

It may be underdiagnosed and frequently misdiagnosed. With proper treatment the chance of death or lasting harm is very low.

TDC overview page (with references): https://thedrugclassroom.com/video/serotonin-toxicity-serotonin-syndrome/

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00:00 – Introduction
02:47 – Effects
06:57 – Diagnosis
08:53 – Prognosis and Treatment
11:49 – Mechanism
17:00 – History
21:21 – Conclusion

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41 Responses to "Overdosing on Serotonin: What to Know About Serotonin Toxicity"

  1. The Drug Classroom   20 February، 2019 at 01:18

    The TDC Patreon has received quite a few new patrons recently, which has been encouraging to see! Thank you to everyone who’s supporting TDC, whether it’s monetarily, by sharing the content, or by just viewing and interacting.

    For this video you can find more information and a references list here: https://thedrugclassroom.com/video/serotonin-toxicity-serotonin-syndrome/

  2. Can’t relate   20 February، 2019 at 01:18

    Pharmacy student over here, very helpful stuff for a couple of my classes, keep it up 😀

  3. frostedlambs   20 February، 2019 at 01:18

    i remember once Micheal Jackson had a prolonged erection from Viagra, so his doctor told him "Just beat it, beat it, beat it, beat it

    No one wants to be defeated"
    ….ill show myself out

  4. tew tadle   20 February، 2019 at 01:18

    This is creepy, I googled overdosing on things like fluoxetine on my second google account on of my laptops and then watched YouTube on my other private account (a different account) on my phone and boom in my recommended I see this.

  5. recepto   20 February، 2019 at 01:18

    Sceletium + psilocybin, later followed by MDMA = sweating+++ , racing pulse, and high temperature. Fortunately he could wade in the ocean to cool down

  6. Crunchy Bee   20 February، 2019 at 01:18

    SSRI gave me muscle twitches that lasted years after off of it. Still have one certain finger twitch every now and then

  7. Dolan Rockwood   20 February، 2019 at 01:18

    I definitely was on the edge of ss when i tripped dxm. Since that trip i just stuck to shrooms and lsd. And recently i stopped those due to hppd symptoms and anxiety. Be careful with your drugs kids.

  8. Nicholas Burkhart   20 February، 2019 at 01:18

    I’ve had this just from taking SSRI’s alone. I’ve had a hospital tell me SSRI drugs could kill me but then had a doctor prescribe me them because they said the alternative anti anxiety drugs can be addictive. I mean personally I’d rather risk possible addiction over death. I later found out the doctor was getting paid extra for each prescription of the SSRI drug.

  9. S U N   20 February، 2019 at 01:18

    Anyone ever take Molly and have their vision start flickering and flashing? I'm pretty sure I Oded back 2017, I never went to the hospital I just waited it out and was by my best friend during it. It also cured my addiction to weed completely anybody else have a similar experience?

  10. pawlak 3   20 February، 2019 at 01:18

    Very educational keep it up 👍

  11. FetchQuestAssigner4423   20 February، 2019 at 01:18

    They may also be playing with glow sticks.

  12. 307 Fishing   20 February، 2019 at 01:18

    What about meth

  13. Amanda Rickert   20 February، 2019 at 01:18

    I don't understand the words coming out of your mouth! Lol… just saying, unless you're a Dr. Who understands this mumbo jumbo? This is utube not a medical conference!!

  14. Paul Kelly   20 February، 2019 at 01:18

    I'm tryna see some nice videos about diphenhydramine/dimenhydrinate. Sleep aid/benadryl and shit about them

  15. Texcoco   20 February، 2019 at 01:18

    These videos are always well made. Props to you!

  16. Equinsu Ocha!   20 February، 2019 at 01:18

    Lexapro and Wellbutrin?

  17. A.C. Jelly   20 February، 2019 at 01:18

    A friend of mine had serotonin syndrome because she was given a huge dose of citalopram by mistake instead of the usual starting dose of 10/20mg.

  18. Monkeybone   20 February، 2019 at 01:18

    I got this when I took a large dose of antidepressants

  19. eric t   20 February، 2019 at 01:18

    I used to be on the smallest dose of Paxil available. I took a 5 HTP pill and my heart was racing, sweating profusely, I was about to call 911 but I passed out while trying, I couldn't even operate my phone. When I woke up I was surprised as I really thought I was going to die.

  20. Death Squared   20 February، 2019 at 01:18

    Great topic!!
    I was just wondering about this!

  21. Yole   20 February، 2019 at 01:18

    my girlfriend overdosed on mdma after taking it for the first time , when she was on her molly her eyes started going everywhere ,after the trip she felt better but now a few months later she kant keep her foot still and has mood swings , are these sypmtoms of ST?

  22. Unwanted   20 February، 2019 at 01:18

    Good that my body doesnt make serotonin

  23. Gui Kirsch   20 February، 2019 at 01:18

    DXM+imposter acid
    That'll do it to ya

  24. IRION IKE   20 February، 2019 at 01:18

    once had episode with NMS, seized for 36 hours in ER. the pain and rolling cramps through my chest were nightmarish, the memories of pysch dreams are very much still vivid. cured addiction pretty well though, thanks doc

  25. NightFiend   20 February، 2019 at 01:18

    dxm and Molly…. never afuckingain….

  26. J Kerfont   20 February، 2019 at 01:18

    Man I havnt received a notification from your channel in lie 4mths. I thought it was shutdown that why im here again and stoked stoked!!!!

  27. Jeremiah Williams   20 February، 2019 at 01:18

    You should do an episode on diethyl ether

  28. Reptillian   20 February، 2019 at 01:18

    One time I snorted two pink 10 mg pills of Oxycontin while taking Prozac and it gave me heart palpitations and I felt like I might go into shock, I think this is what happened.

  29. Josh doe   20 February، 2019 at 01:18

    Is there any way to get in direct contact with you?

  30. Andrew Murphy   20 February، 2019 at 01:18

    Hey can you make a video on methadone

  31. BarneyPete   20 February، 2019 at 01:18

    Does being on zoloft and smoking weed casue this

  32. Vit Sir   20 February، 2019 at 01:18

    I'm on Effexor and Wellbutrin

  33. fyighfreak   20 February، 2019 at 01:18

    Is it just me or do you not have a SINGLE video called "LSD: What You Need To Know"??
    Are you waiting for the perfect time or do you simply not plan on covering it?
    I'm a huge fan btw.

  34. ゼロRe   20 February، 2019 at 01:18


  35. Gl00m   20 February، 2019 at 01:18

    What happened to your nicotine what we know?

  36. lucky anson   20 February، 2019 at 01:18

    Was put into a medically induced coma for 10 days and had to be put on a breathing machine and developed rhabdomyolysis along with seizures that still continue and are tonic clonic in nature. My personal extermination wasnt worth it

  37. DragonOfTheSkies   20 February، 2019 at 01:18

    I ended up in the emergency room from ST after stupidly mixing Lexapro and Trazodone. The ER doctor didn’t know what the hell was wrong with me, even though I included both of those on the list of medications I had been taking. It wasn’t until weeks later when I talked to the doctor who prescribed me the Lexapro that I got properly diagnosed with ST. So yeah, doctors (and people in general) need to be more aware of it.

    In case anyone is wondering, Trazodone is sometimes prescribed for sleep (even though it’s primarily an antidepressant). I had some left over from a different doctor than the one who was giving me Lexapro. I was having a difficult time getting sleep for a few days so I started taking the Trazodone again at night. Boy was that a mistake. It made my blood pressure skyrocket and I had trouble moving the left side of my body and making coherent sentences. But with all the serotonin in my system, I was the happiest motherf*cker in that ER…

  38. OnlineDater69   20 February، 2019 at 01:18

    I took 500mg pure MDMA one time on accident & thank God I took magnesium before. Didn't get ST. Although it wasn't pleasant. Good video btw!

  39. souleater   20 February، 2019 at 01:18

    Would you ever do a podcast with CGKid? Btw love the content keep it up

  40. android junki3   20 February، 2019 at 01:18

    I had serotonin syndrome once. One of the scariest things I've ever experienced. Thumping heartbeat, no balance whatsoever, and hallucinations for a couple days. It took a week to go away all of the way.

  41. sYRINGE!   20 February، 2019 at 01:18

    Wow, your videos are realy good!


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