✅ Video with information about ondansetron (zofran): Side effects, uses, indications, contraindications, warnings,precautions, interactions, mechanism of action (moa), trade name (zofran, zofran odt) and answers to questions like: what is ondansetron?, What is ondansetron used for?.❤️ Suscribe: https://www.youtube.com/c/MedicinesDiseases?sub_confirmation=1
What is ondansetron odt?
Ondansetron odt, odansetron hcl is a drug used for the treatment of nausea and vomiting and as a post-chemotherapy treatment.
The most commonly used doses of ondansetron are ondansetron 4mg and ondansetron 8 mg (injection, tablets).
The trade name of ondansetron is zofran odt or zofran.
Ondansetron mechanism of action (moa):
Powerful and highly selective antagonist of 5-HT3 receptors located in peripheral neurons and within the CNS.
Ondansetron side effects:
Headache; hot flashes; constipation; local reactions instead of intravenous injection.
Hypersensitivity to the active substance or other 5-HT3 antagonists; concomitant use with apomorphine.
Contraindicated with: apomorphine.
Plasma concentrations reduced by: CYP3A4 inducers (phenytoin, carbamazepine, rifampicin).
Risk of serotonergic syndrome (altered mental state, autonomic instability, neuromuscular anomalies) with: serotonergic drugs (SSRI, SNRI).
May reduce analgesic effect of: tramadol (small studies).
Further extension of QT interval with: QT prolonging drugs.
Increased risk of arrhythmias with: cardiotoxic drugs (e.g. anthracyclines such as doxorubicin, daunorubicin or trastuzumab; antibiotics such as erythromycin or ketoconazole; antiarrhythmics such as amiodarone and beta blockers such as atenolol or timolol).
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