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What is diltiazem?
Diltiazem is a drug used for the treatment of hypertension.
The trade names of diltiazem are: Cardizem, Cartia XT, Diltiazem Hydrochloride CD, Cardizem CD.
Mechanism of action of diltiazem:
Diltiazem selectively limits calcium entry through the slow calcium channels of vascular smooth muscle and myocardial muscle fibers in a voltage-dependent manner. By means of this mechanism, diltiazem reduces the concentration of intracellular calcium.
Therapeutic indications, uses, benefits and posology of diltiazem:
Oral. Adults. There are two types of preparations for the oral route: fast release (distribute the dose in 2-3 doses) and prolonged release (allows a single daily dose). Recommended dosage:
Treatment and prevention of angina: start: 60 mg/12 h, maintenance: 180-360 mg/day in one or several doses depending on the preparation. In unstable angina the maximum dose is 480 mg/day.
Hypertension: onset 120-240 mg/day, maintenance: 180-360 mg/day in one or more doses depending on the preparation. The maximum antihypertensive effect is normally observed after 14 days of treatment. Max. dose: 360 mg/day.
Warnings and precautions for diltiazem:
Elderly; anaesthesia; patients at risk of developing an intestinal obstruction, diabetes mellitus. Monitoring of liver and kidney function. Regular control of the cardiac rhythm. Risk of symptomatic hypotension, depression. Not recommended for children.
Side effects of diltiazem:
Headache, dizziness; atrioventricular block, palpitations; constipation, dyspepsia, gastric pain, nausea; erythema, rash; edema of the lower limbs.